Health Benefits of KEFPEP®

Antihypertension & Cardiovascular Care

KEFPEP® has revealed antihypertensive activities on in vivo assays using Spontaneously Hypertensive Rats (SHR) and Spontaneously Hypertensive Stroke-Prone Rats (SHRSP). Clinical trials have also demonstrated that KEFPEP® lowers Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) in patients with prehypertension.

In addition, Administration of KEFPEP® protects the cardiovascular system against hypertension or high-salt diet-induced stresses. Following ingestion of high salt concentration, KEFPEP® has been found to protect the cardiovascular system, including aortic arch, renal artery, and cerebral artery, as well as ameliorate inflammation, thickening, and arteriosclerosis. Experimental results and clinical outcomes consistently suggest that KEFPEP® is an efficient peptide-based ingredient for blood pressure regulation and cardiovascular protection.

Bone Mineral Density Elevation

Ovariectomized rats are the commonly used animal model for mimicking osteoporosis in menopausal women. In ovariectomized rats, administration of KEFPEP® efficiently prevents the degeneration of trabecular bone and attenuates the decrease in bone mineral density (BMD). Therefore, treatment with KEFPEP® provides obvious benefits in maintaining structure and function of bone. The results of our clinical trial indicate that administration of KEFPEP® elevates serum Parathyroid Hormone (PTH) and suppresses osteoclast activity. Elevated PTH level then leads to bone formation activation. Therefore, treatment with KEFPEP® helps maintain and even increase BMD in patients with osteopenia and mild osteoporosis.

Fatty Liver Prevention

KEFPEP® has been shown to prevent fat accumulation in hepatocytes of leptin-deficient obese mice by suppressing the lipogenesis pathway. In addition, treatment with KEFPEP® significantly prevents the occurrence of fatty liver, even when the mice constantly drink water containing 30% fructose. Collectively, KEFPEP® is an efficient dietary supplement for preventing fatty liver.